Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach.
نویسندگان
چکیده
Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities and as single diastereoisomers.
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عنوان ژورنال:
- Chemical communications
دوره 50 4 شماره
صفحات -
تاریخ انتشار 2014